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It is not recommended during pregnancy or while breastfeeding

[146] Healthcare providers should educate patients about the expected timeline for therapeutic response and should emphasize the importance of medication adherence during the initial weeks of treatment when side effects may be more prominent than therapeutic benefits

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However, the extent and clinical significance of direct brain delivery for wolverine stack peptides requires further study

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In rodent models, it has been associated with improved motor function after focal stroke and reduced infarct size in brain infarction studies